ABSTRACT
Background: Many studies in the past have revealed the prevalence of hyperuricemia and microalbuminuria in hypertensive individuals and both are the well known markers of end organ damage. But there are very few studies which have demonstrated the prevalence of hyperuricemia and microalbuminuria in prehypertensive individuals in Indian clinical scenario so that we can identify the prehypertensive individuals at risk of subclinical organ damage by simply measuring these parameters. Objective: To study the prevalence of hyperuricemia and microalbuminuria in prehypertension. Methods: Study was done on both male and female prehypertensive patients of age more than 18 years and less than 60, admitted in wards and attending OPD under the Department of Medicine, NIMS Hospital, Jaipur. Controls were normotensive patients admitted in wards who were matched for age, sex and confounding factors. Results: Hyperuricemia was found in 47(15.67%) patients with prehypertension compared to 29(9.67%) patients with normal BP .Microalbuminuria (quantitative) was found in 51(17%) patients with Prehypertension compared to 31(10.33%) patients with normal BP. The study showed that subjects in prehypertensive group had serum uric acid values distributed more widely in the IIIrd and IVth quartiles than in the Ist and IInd quartiles, whereas subjects in control group had serum uric acid values with greater distribution, in the Ist and IInd quartiles than in the IIIrd and IVth quartiles. Conclusion: We found that microalbuminuria and hyperuricemia are significantly more prevalent among prehypertensive subjects as compared to normotensive subjects so that measurement of these parameters can serve as low cost, accurate & reliable clinical tool to identify prehypertensive patient at higher risk of subclinical target organ damage.
ABSTRACT
Background: Myocardial infarction, it still continues to be a major health problem worldwide. The aim of the study is to find out incidence of impaired glucose tolerance in non-diabetic patients with acute coronary syndrome. Methods: The study includes 50 patients. All the cases and controls were subjected to standard 75 gms. Oral Glucose Tolerance Test (OGTT) on admission, at the time of discharge and at three months follow-up and the observations were recorded. Results: Post prandial blood sugar at time 3 month follow up were 6 (12%) in cases and 9 (18%) in control but not significant statistically. There were 17 (34%) cases and 7 (14%) in control with IGT values which was statistically significant p= 0.034. Post prandial blood sugar at time of admission were 131.18 ± 21.52 in cases, 121.86 ± 21.47 in controls and at the time discharge in cases and controls were 139.10 ± 21.27 and 128.88 ± 9.44 respectively with p=0.003. Conclusion: Patients with acute coronary syndrome who have IGT on admission have longer hospital stay and more complications related to acute MI.
ABSTRACT
Background: Metabolic syndrome (MetS) is a multiplex of metabolic risk factors including abdominal obesity, hypertension, atherogenic dyslipidemia and insulin resistance.The study is aimed to find causes and aetiological factors responsible for metabolic syndrome prevailing in and around Jaipur, both in rural and urban areas.Methods: It involves measurement of height, weight, blood pressure, fasting blood glucose, triglycerides and HDL levels. Results: In our study, overall prevalent rates of MetS in adolescents is 6.8% and in adults, it is 50.4%. According to present study, TGs, high blood pressure and low HDL were found to be major contributing factors for MetS in adolescents whereas in adults abdominal obesity contributed the most. Conclusion: These findings prove to be important tools to screen out MetS positive subjects because it is one of the leading risk factors of CVD, DM and stroke posing an emerging health problem to old and the new stressed out younger generation.